ACTIVE SUBSTANCE

Abobotulinumtoxina Acarbose Acetyl hexapeptide-8 Adalimumab Adipotide Albuterol Alpha-Melanocyte Alfuzosin Amiodarone Amlodipine Amoxycillin Amoxycillin Clavulanate Amoxycillin Trihydrate Anastrozole Andarine Anti-Obesity Drug-9604 Arimistane Atorvastatin Avanafil Azithromycin Bacteriostatic Water Betamethasone Betahistine Betamethasone valerate Bimatoprost Boldenone Undecylenate BPC-157 Bremelanotide Bromocriptine Cabergoline Candesartan Cilexetil Cefalexin Cefdinir Cefixime Cefuroxime Ciprofloxacin Chlorodehydro Methyltest Clarithromycin Clenbuterol Clobetasol Propionate Clomiphene Citrate Clopidogrel Colecalciferol Copper peptide GHK-Cu Cyproterone Dabigatran Dapoxetine Delta sleep-inducing peptide Desloratadine Diclofenac Potassium Dihydroboldenone Cypionate Diosmina Donnazyme Doxazosin Doxycycline Hyclate Drospirenone Drostanolone Di-Propionat Drostanolone Enanthate Drostanolone Propionate Duloxetine Dutasteride Dydrogesterone Enoxaparin Sodium Epitalon Erythropoietin Esomeprazole Etanercept Ethinyl Estradiol Examorelin Exemestane Finasteride Flibanserin Fluoxetine Fluoxymesterone Fluticasone Follistatin Furosemide GDF-8 inhibitor Gemifloxacin Mesylate GHRH Peptide GHRP Peptide Ginseng Gliclazide Gonadorelin Growth Hormone peptide fragment 176-191 Cardarine Herbal Mix Hesperidina Human Chorionic Gonadotropin Human Menopausal Gonadotropin Human Insulin Hyaluronic acid Hydrochloride Hydrochlorothiazide Hydroquinone Hydroxyzine Ibutamoren Ibuprofen IGF-1 DES IGF-1 LR3 Imiquimod Immune globulin Insulin Inosine Monophosphate Insulin Glargine Insulin Glulisine Insulin Isophane Insulin Lispro Insulin Lispro Protamine Suspension Ipamorelin Ipratropium Bromide Isotretinoin Ketotifen L-Ornithine L-Aspartate Lacidipine Lansoprazole Leflunomide Letrozole Levofloxacin LGD-4033 Lidocaine Losartan Levothyroxine Sodium Liothyronine Sodium Lisinopril Mebeverine Hydrochloride Mechano Growth Factor Melanocyte-stimulating hormone (MSH) Mesterolone Metformin Metformin Hydrochloride Methandienone Methandienone Injectable Methandienone Suspension Methenolone Acetate Methenolone Enanthate Methimazole Methyl-1-Testosterone Methyldrostanolone Methylnortestosterone Acetate Methyltrienolone Metoprolol Metronidazole Miconazole Nitrate MK-2866 mod GRF (1-29) Montelukast Sodium Moxifloxacin Multivitamin Myostatin Nandrolone Decanoate Nandrolone Laurat Nandrolone Phenylpropionate Nandrolone Propionate Nandrolone Undecanoate Onabotulinumtoxina Orlistat Ostarine Oxandrolone Oxymetholone Oxymetholone Injectable Oxytocin Palmitoyl Tripeptide-1 Pimecrolimus Pioglitazone Pegylated Mechano Growth Factor Penicillin Perindopril Arginine Prednisolone Pyridostigmine Pyridoxine Raloxifene Retinoic Acid Rho(D) immune globulin Rivaroxaban Rosuvastatin S-23 Safed Musli Salmeterol Selank Semax Sibutramine Sildenafil Silymarin Sitagliptin Sodium Hyaluronate Sodium fusidat Solifenacin Somatropine - 191 Amino Acid Spiramycin Spironolactone Stanozolol Stanozolol Base Stanozolol Injectable Stanozolol Suspension Stenabolic T3 Triiodothyronine Tadalafil Tamoxifen Citrate Telmisartan Tesamorelin acetate Testolone Testosterone Acetate Testosterone Cypionate Testosterone Decanoate Testosterone Enanthate Testosterone Gel Testosterone Isocaproate Testosterone Phenylpropionate Testosterone Propionate Testosterone Suspension Testosterone Undecanoate Thiamine Thiocolchicoside Thymosin beta-4 Ticagrelor Tioconazole Tiotropium bromide Tolterodine Toremifene Citrate Trenbolone Acetate Trenbolone Base Trenbolone Enanthate Trenbolone Hexahydrobenzylcarbonate Trenbolone Suspension Triamterene Hydrochlorothiazide Triptorelin Udenafil Ursodeoxycholic acid Valacyclovir Valproic Acid Valsartan Vardenafil Varenicline Vitamin A Vitamin B1 Vitamin B2 Vitamin B3 Vitamin B5 Vitamin B6 Vitamin B9 Vitamin B12 Vitamin C Vitamin D Vitamin E Vitamin K1 YK-11 Yohimbine Zinc Sulfate

ROAS

$70.00
Quanity:
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Characteristics

  • Chemical name: 13-cis retinoic acid
ACTIVE HALF-LIFE
20-22 hours
Classification
Dermatotropic drug
Dosage
10-40 mg/day
ACNE
No
WATER RETENTION
No
HBR
No
HEPATOTOXICITY
Yes
AROMATIZATION
No
Active Substance
FORM
50 pills x 10 mg
Manufacturer

Description

  • Chemical name: 13-cis retinoic acid

 

 

ROAS

 

Isotretinoin, also known as 13-cis retinoic acid is an oral pharmaceutical drug primarily used to treat acne. Rarely, it is also used to prevent certain skin cancers, the treatment of other cancers. It is used to treat harlequin-type ichthyosis, a usually lethal skin disease, and lamellar ichthyosis.

It is a retinoid, meaning it is related to vitamin A, and is found in small quantities naturally in the body.

Isotretinoin amplifies production of neutrophil gelatinase-associated lipocalin (NGAL) in the skin, which has been shown to reduce sebum production by inducing apoptosis in sebaceous gland cells, while exhibiting an antimicrobial effect on Propionibacterium acnes. The drug decreases the size and sebum output of the sebaceous glands. Isotretinoin is the only available acne drug that affects all four major pathogenic processes in acne, which distinguishes it from alternative treatments (such as antibiotics) and accounts for its efficacy in severe, nodulocystic cases.

Oral Isotretinoin is best absorbed when taken with a high-fat meal, because it has a high level of lipophilicity. The efficacy of isotretinoin doubles when taken after a high-fat meal compared to when taken without food. Due to Isotretinoin's molecular relationship to Vitamin A, it should not be taken with Vitamin A supplements due to the danger of toxicity through cumulative overdosing.

Isotretinoin is the most effective drug for treating acne on the market. The most common adverse effects are a transient worsening of acne (lasting 2–3 weeks), dry lips, dry and fragile skin, and an increased susceptibility to sunburn. Uncommon and rare side effects include: muscle aches and pains, and headaches.

Isotretinoin is known to cause birth defects due to in utero exposure because of the molecule's close resemblance to retinoic acid, a natural vitamin A derivative which controls normal embryonic development. There is about a 20%–35% risk for congenital defects in infants exposed to the drug in utero, and about 30%–60% of children exposed to isotretinoin prenatally have been reported to show neurocognitive impairment. Because of this, there are strict controls on prescribing isotretinoin to women who may become pregrant and women who become pregnant while taking isotretinoin are strongly advised to terminate their pregnancies.

WARNING: ONCE AGAIN DO NOT USE ROAS IF YOU ARE PREGNANT OR MAY BECOME PREGNANT!

Customer Reviews


03.10.2018
Accutanemane
Rating: EXCELLENT
Verified Purchase
Loved the product, great efficacy. Will be ordering more because the first time was such a great experience. Packaging and shipping times were on point. Far better than purchasing research chems! Keep up the great quality, I will be a regular customer.
28.09.2018
Lifesgood
Rating: EXCELLENT
Verified Purchase
After trying several other companies, PharmaComStore is hands down the best in terms of quality and service. And I can't complain about the shipping time as it is about the same as if I were to order from the US.
19.03.2018
J
Rating: EXCELLENT
Verified Purchase
Ive been using this accutane for approximately 5 weeks and notice my skin clearing up nicely , i started taking 20mg a day now that ive cleared up ive lowered to 10mg hoping that it keeps the acne away !!! Thanks
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